Lithium-induced NDI in rats is associated with loss of -ENaC regulation by aldosterone in CCD
نویسندگان
چکیده
Jakob Nielsen, Tae-Hwan Kwon, Jørgen Frøkiær, Mark A. Knepper, and Søren Nielsen The Water and Salt Research Center and Institute of Anatomy, University of Aarhus, Aarhus, Denmark; Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Taegu, Korea; Institute of Clinical Medicine, University of Aarhus, Aarhus, Denmark; and Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
منابع مشابه
Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI.
Lithium-induced nephrogenic diabetes insipidus is associated with increased renal sodium excretion in addition to severe urinary concentrating defects. However, the molecular basis for this altered renal sodium excretion remains undefined. The amiloride-sensitive sodium channel (ENaC) is expressed in the renal connecting tubule and collecting duct and is essential in renal regulation of body so...
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Edema and ascites in nephrotic syndrome mainly result from increased Na+ reabsorption along connecting tubules and cortical collecting ducts (CCD). In puromycin aminonucleoside (PAN)-induced nephrosis, increased Na+ reabsorption is associated with increased activity of the epithelial sodium channel (ENaC) and Na+,K+-ATPase, two targets of aldosterone. Because plasma aldosterone increases in PAN...
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Aldosterone induces redistribution of epithelial sodium channel (ENaC) to the apical plasma membrane from intracellular vesicles in renal connecting tubule (CNT) and cortical collecting duct (CCD). The role of the classical mineralocorticoid receptor (MR) in ENaC trafficking is still debated. We examined whether the MR antagonist spironolactone affects ENaC regulation in the kidney cortex of al...
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By virtue of its unique interactions with kidney cells, lithium became an important research tool in renal physiology and pathophysiology. Investigators have uncovered the intricate relationships of lithium with the vasopressin and aldosterone systems, and the membrane channels or transporters regulated by them. While doing so, their work has also led to 1) questioning the role of adenylyl cycl...
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